._page_16bwb_1{--navy:#122b48;--ink:#16273a;--blue:#2f628f;--paper:#fffaf5;--cream:#f3ede4;--soft:#f8f5f0;--line:#122b4829;background:var(--paper);color:var(--ink);font-family:var(--font-site);min-width:0;overflow:visible}._page_16bwb_1 *,._page_16bwb_1 :before,._page_16bwb_1 :after{box-sizing:border-box}._page_16bwb_1 :is(h1,h2,h3,p,dl,dd,ol,ul){margin-top:0}._page_16bwb_1 :is(h1,h2,h3){color:var(--navy);font-family:var(--font-site);text-wrap:balance;font-weight:600}._page_16bwb_1 a{color:inherit;text-underline-offset:4px}._page_16bwb_1 :is(a,[tabindex]):focus-visible{outline:3px solid var(--blue);outline-offset:4px}._breadcrumbs_16bwb_22{border-bottom:1px solid var(--line);max-width:1500px;padding:calc(var(--a1-header-height,86px) + 16px) clamp(20px, 4.5vw, 72px) 16px;flex-wrap:wrap;align-items:center;gap:9px;margin:0 auto;display:flex}._breadcrumbs_16bwb_22 :is(a,span,strong){font-size:12px;line-height:1.45}._breadcrumbs_16bwb_22 a{color:var(--blue)}._breadcrumbs_16bwb_22 span{color:#16273a66}._hero_16bwb_36{grid-template-columns:minmax(0,1.35fr) minmax(320px,.65fr);gap:clamp(42px,6vw,92px);max-width:1500px;margin:0 auto;padding:clamp(48px,6vw,92px) clamp(20px,4.5vw,72px);display:grid}._heroCopy_16bwb_44{align-self:center;min-width:0}._eyebrow_16bwb_45,._scopeCard_16bwb_45>p:first-child,._tocInner_16bwb_45>p,._patientBridge_16bwb_45>p:first-child{color:var(--blue);letter-spacing:.14em;text-transform:uppercase;margin-bottom:18px;font-size:12px;font-weight:600}._hero_16bwb_36 h1{letter-spacing:-.05em;max-width:18ch;margin-bottom:28px;font-size:clamp(40px,4.8vw,72px);line-height:1.02}._dek_16bwb_54{max-width:66ch;margin-bottom:34px;font-size:clamp(18px,1.4vw,22px);line-height:1.62}._meta_16bwb_55{border-bottom:1px solid var(--line);border-top:1px solid var(--line);grid-template-columns:repeat(3,minmax(0,1fr));display:grid}._meta_16bwb_55>div{padding:17px 20px 17px 0}._meta_16bwb_55>div+div{border-left:1px solid var(--line);padding-left:20px}._meta_16bwb_55 dt{color:var(--blue);letter-spacing:.1em;text-transform:uppercase;margin-bottom:6px;font-size:10px;font-weight:600}._meta_16bwb_55 dd{margin:0;font-size:13px;line-height:1.5}._scopeCard_16bwb_45{background:var(--navy);color:var(--paper);align-self:center;padding:clamp(30px,4vw,54px)}._scopeCard_16bwb_45>p:first-child{color:#b9d1e5}._scopeCard_16bwb_45 h2{color:var(--paper);margin-bottom:22px;font-size:clamp(25px,2.1vw,34px);line-height:1.15}._scopeCard_16bwb_45>p:not(:first-child){color:#fffaf5d6;font-size:15px;line-height:1.72}._scopeCard_16bwb_45 a,._patientBridge_16bwb_45 a{border-top:1px solid #ffffff3b;justify-content:space-between;align-items:center;gap:14px;margin-top:28px;padding-top:18px;font-size:14px;font-weight:600;display:flex}._readingLayout_16bwb_67{border-top:1px solid var(--line);grid-template-columns:minmax(220px,270px) minmax(0,1fr);max-width:1840px;margin:0 auto;padding:0 clamp(20px,2.6vw,48px) clamp(72px,8vw,120px);display:grid}._toc_16bwb_45{border-right:1px solid 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0;scroll-margin-top:110px}._section_16bwb_77>h2{letter-spacing:-.035em;max-width:24ch;margin-bottom:32px;font-size:clamp(30px,3.3vw,48px);line-height:1.08}._section_16bwb_77[data-section-tone=scope]{background:linear-gradient(90deg,#f3ede4b3,#0000);margin-left:calc(-1*clamp(32px,5vw,86px));padding-left:clamp(32px,5vw,86px)}._section_16bwb_77[data-section-tone=summary] ._sectionContent_16bwb_80{background:var(--soft);border-left:4px solid var(--blue);padding:clamp(24px,3vw,38px)}._sectionContent_16bwb_80{max-width:1040px}._sectionContent_16bwb_80 p,._sectionContent_16bwb_80 li{font-size:17px;line-height:1.78}._sectionContent_16bwb_80 p{margin-bottom:22px}._sectionContent_16bwb_80 h3{margin:38px 0 15px;font-size:clamp(21px,2vw,27px)}._sectionContent_16bwb_80 ul{gap:14px;margin:0;padding-left:22px;display:grid}._sectionContent_16bwb_80 a{color:var(--blue);overflow-wrap:anywhere}._evidenceNotice_16bwb_88{background:var(--navy);color:var(--paper);margin-bottom:28px;padding:22px 24px;font-size:15px;line-height:1.7}._tableScroller_16bwb_89{border:1px solid var(--line);width:100%;overflow-x:auto}._tableScroller_16bwb_89 table{border-collapse:collapse;table-layout:fixed;width:100%}._tableScroller_16bwb_89 caption{clip:rect(0 0 0 0);clip-path:inset(50%);white-space:nowrap;width:1px;height:1px;position:absolute;overflow:hidden}._tableScroller_16bwb_89 :is(th,td){-webkit-hyphens:auto;hyphens:auto;overflow-wrap:anywhere;word-break:normal}._tableScroller_16bwb_89 th{background:var(--navy);color:var(--paper);letter-spacing:.025em;text-align:left;vertical-align:bottom;padding:13px 11px;font-size:11px;line-height:1.35}._tableScroller_16bwb_89 td{border-bottom:1px solid var(--line);border-right:1px solid var(--line);vertical-align:top;padding:14px 11px;font-size:12px;line-height:1.52}._tableScroller_16bwb_89 :is(th,td):first-child,._tableScroller_16bwb_89 :is(th,td):nth-child(2){width:11%}._tableScroller_16bwb_89 :is(th,td):nth-child(3){width:10%}._tableScroller_16bwb_89 :is(th,td):nth-child(4){width:9%}._tableScroller_16bwb_89 :is(th,td):nth-child(5),._tableScroller_16bwb_89 :is(th,td):nth-child(6){width:13%}._tableScroller_16bwb_89 :is(th,td):nth-child(7){width:11%}._tableScroller_16bwb_89 :is(th,td):nth-child(8){width:12%}._tableScroller_16bwb_89 :is(th,td):nth-child(9){width:10%}._tableScroller_16bwb_89 td[data-primary=true]{color:var(--navy);font-weight:600}._tableScroller_16bwb_89 tbody tr:nth-child(2n){background:var(--soft)}._references_16bwb_107 ol{margin:0;padding:0;list-style:none}._references_16bwb_107 li{border-top:1px solid var(--line);grid-template-columns:42px minmax(0,1fr);gap:20px;padding:20px 0;display:grid}._references_16bwb_107 li>span{color:var(--blue);letter-spacing:.1em;font-size:12px;font-weight:600}._references_16bwb_107 p{margin-bottom:8px;font-size:14px;line-height:1.65}._references_16bwb_107 a{color:var(--blue);font-size:13px;font-weight:600}._patientBridge_16bwb_45{background:var(--navy);color:var(--paper);text-align:center;grid-column:1/-1;margin-top:clamp(48px,6vw,86px);padding:clamp(42px,6vw,76px)}._patientBridge_16bwb_45>p:first-child{color:#b9d1e5}._patientBridge_16bwb_45 h2{color:var(--paper);max-width:30ch;margin:0 auto 20px;font-size:clamp(28px,3vw,42px);line-height:1.1}._patientBridge_16bwb_45>p:not(:first-child){color:#fffaf5d1;max-width:68ch;margin-left:auto;margin-right:auto;font-size:16px;line-height:1.7}._patientBridge_16bwb_45 a{justify-content:center;max-width:720px;margin-left:auto;margin-right:auto}@media (width<=980px){._hero_16bwb_36{grid-template-columns:1fr}._hero_16bwb_36 h1{max-width:none}._readingLayout_16bwb_67{grid-template-columns:1fr}._toc_16bwb_45{border-bottom:1px solid var(--line);border-right:0;padding-right:0}._tocInner_16bwb_45{max-height:none;padding-right:0;position:static;overflow:visible}._toc_16bwb_45 ol{grid-template-columns:repeat(2,minmax(0,1fr));gap:0 24px;display:grid}._body_16bwb_76{padding-left:0}._section_16bwb_77[data-section-tone=scope]{margin-left:0;padding-left:0}._tableScroller_16bwb_89 table{table-layout:fixed;min-width:1320px}}@media (width<=680px){._hero_16bwb_36{padding-top:38px}._hero_16bwb_36 h1{font-size:clamp(35px,11vw,52px)}._meta_16bwb_55{grid-template-columns:1fr}._meta_16bwb_55>div+div{border-left:0;border-top:1px solid var(--line);padding-left:0}._toc_16bwb_45 ol{grid-template-columns:1fr}._sectionContent_16bwb_80 p,._sectionContent_16bwb_80 li{font-size:16px}}@media print{._toc_16bwb_45,._breadcrumbs_16bwb_22{display:none}._hero_16bwb_36,._readingLayout_16bwb_67{max-width:none;padding:20px;display:block}._scopeCard_16bwb_45,._patientBridge_16bwb_45,._evidenceNotice_16bwb_88{color:#000;background:0 0;border:1px solid #888}._scopeCard_16bwb_45 :is(h2,p,a),._patientBridge_16bwb_45 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